Dataset Information
Cryo electron microscopy unaligned movie frames for single particle analysis of the Escherichia coli 70S ribosome with Myxovalargin B
Ontology highlight
ABSTRACT:
SUBMITTER: Timm Oliver Koller
PROVIDER: EMPIAR-12403 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The Myxobacterial Antibiotic Myxovalargin: Biosynthesis, Structural Revision, Total Synthesis, and Molecular Characterization of Ribosomal Inhibition.
Journal of the American Chemical Society 20230105 2
Resistance of bacterial pathogens against antibiotics is declared by WHO as a major global health threat. As novel antibacterial agents are urgently needed, we re-assessed the broad-spectrum myxobacterial antibiotic myxovalargin and found it to be extremely potent against <i>Mycobacterium tuberculosis</i>. To ensure compound supply for further development, we studied myxovalargin biosynthesis in detail enabling production via fermentation of a native producer. Feeding experiments as well as func ...[more]