Dataset Information
Cryo-EM structures of SV2A in complex with antiepileptic drugs and botulinum neurotoxin A2 receptor-binding domain
Ontology highlight
ABSTRACT:
SUBMITTER: Atsushi Yamagata
PROVIDER: EMPIAR-12410 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A.
Nature communications 20240418 1
More than one percent of people have epilepsy worldwide. Levetiracetam (LEV) is a successful new-generation antiepileptic drug (AED), and its derivative, brivaracetam (BRV), shows improved efficacy. Synaptic vesicle glycoprotein 2a (SV2A), a putative membrane transporter in the synaptic vesicles (SVs), has been identified as a target of LEV and BRV. SV2A also serves as a receptor for botulinum neurotoxin (BoNT), which is the most toxic protein and has paradoxically emerged as a potent reagent fo ...[more]