Dataset Information
CryoEM structure of a broadly neutralizing anti-SARS-CoV-2 mAb 52
Ontology highlight
ABSTRACT:
SUBMITTER: Goran Bajic
PROVIDER: EMPIAR-12414 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Germinal center-mediated broadening of B cell responses to SARS-CoV-2 booster immunization.
Science immunology 20251010 112
Germinal centers (GCs) are key sites for antibody diversification and affinity maturation. SARS-CoV-2 messenger RNA (mRNA) vaccines elicit robust GC B cell responses in humans, but how these responses influence the breadth of immunity against viral variants remains unclear. We analyzed GC B cell responses in nine healthy adults after mRNA booster immunization. We show that 77.8% of the B cell clones in the GC expressed representative monoclonal antibodies (mAbs) recognizing the spike protein, wi ...[more]