Single particle reconstruction of human apo TRPM8 channel in a closed state
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ABSTRACT:
SUBMITTER: Mariusz Czarnocki-Cieciura
PROVIDER: EMPIAR-12443 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of human TRPM8 channel.
Palchevskyi Sergii S Czarnocki-Cieciura Mariusz M Vistoli Giulio G Gervasoni Silvia S Nowak Elżbieta E Beccari Andrea R AR Nowotny Marcin M Talarico Carmine C
Communications biology 20231019 1
TRPM8 is a non-selective cation channel permeable to both monovalent and divalent cations that is activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality. It is a therapeutic target for anticancer drug development, and its modulators can be utilized for several pathological conditions. Here, we present a cryo-electron microscopy structure of a human TRPM8 channel in the closed state that was solved at 2.7 Å resolution. Our structure comprises the most com ...[more]
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