Dataset Information
Cryo-EM Structure of the Full-length hnRNPA1 Amyloid Fibril
Ontology highlight
ABSTRACT:
SUBMITTER: Matthias Schmidt
PROVIDER: EMPIAR-12447 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM Structure of the Full-length hnRNPA1 Amyloid Fibril.
Journal of molecular biology 20230720 18
Heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) is a multifunctional RNA-binding protein that is associated with neurodegenerative diseases, such as amyotrophic lateral sclerosis and multisystem proteinopathy. In this study, we have used cryo-electron microscopy to investigate the three-dimensional structure of amyloid fibrils from full-length hnRNPA1 protein. We find that the fibril core is formed by a 45-residue segment of the prion-like low-complexity domain of the protein, whereas the r ...[more]