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Micrographs that led to the structure of Dia1 on F-actin

ABSTRACT:

SUBMITTER: Roberto Dominguez

PROVIDER: EMPIAR-12455 | biostudies-other |

REPOSITORIES: biostudies-other

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Mechanisms of actin filament severing and elongation by formins.

Palmer Nicholas J NJ Barrie Kyle R KR Dominguez Roberto R

Nature 20240606 8024

Humans express 15 formins that play crucial roles in actin-based processes, including cytokinesis, cell motility and mechanotransduction<sup>1,2</sup>. However, the lack of structures bound to the actin filament (F-actin) has been a major impediment to understanding formin function. Whereas formins are known for their ability to nucleate and elongate F-actin<sup>3-7</sup>, some formins can additionally depolymerize, sever or bundle F-actin. Two mammalian formins, inverted formin 2 (INF2) and dia ...[more]

PMID: 38843827

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