Dataset Information
Cryo-ET dataset of FIB-milled mock infected (control) human monocyte-derived macrophages
Ontology highlight
ABSTRACT:
SUBMITTER: Martin Beck
PROVIDER: EMPIAR-12457 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Passage of the HIV capsid cracks the nuclear pore.
Cell 20250117 4
Upon infection, human immunodeficiency virus type 1 (HIV-1) releases its cone-shaped capsid into the cytoplasm of infected T cells and macrophages. The capsid enters the nuclear pore complex (NPC), driven by interactions with numerous phenylalanine-glycine (FG)-repeat nucleoporins (FG-Nups). Whether NPCs structurally adapt to capsid passage and whether capsids are modified during passage remains unknown, however. Here, we combined super-resolution and correlative microscopy with cryoelectron tom ...[more]