Single particle cryoEM data of Nucleosome core particle containing an 8-oxoG damage site
Ontology highlight
ABSTRACT:
SUBMITTER: Qignlong You
PROVIDER: EMPIAR-12495 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Human 8-oxoguanine glycosylase OGG1 binds nucleosome at the dsDNA ends and the super-helical locations.
You Qinglong Q Feng Xiang X Cai Yi Y Baylin Stephen B SB Li Huilin H
Communications biology 20240928 1
The human glycosylase OGG1 extrudes and excises the oxidized DNA base 8-oxoguanine (8-oxoG) to initiate base excision repair and plays important roles in many pathological conditions such as cancer, inflammation, and neurodegenerative diseases. Previous structural studies have used a truncated protein and short linear DNA, so it has been unclear how full-length OGG1 operates on longer DNA or on nucleosomes. Here we report cryo-EM structures of human OGG1 bound to a 35-bp long DNA containing an 8 ...[more]
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