Dataset Information
Cryo-EM structure of CorA in complex with conformation-specific synthetic antibody C18 and 100 uM MgCl2
Ontology highlight
ABSTRACT:
SUBMITTER: Satchal Krishna Erramilli
PROVIDER: EMPIAR-12500 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.
Proceedings of the National Academy of Sciences of the United States of America 20260217 8
In prokaryotes, CorA is the primary influx pathway for magnesium, a critical divalent cation in cellular physiology and biochemistry. Mechanistic studies show that homopentameric CorA is regulated through an intracellular [Mg<sup>2+</sup>]-dependent negative feedback loop, involving the asymmetric participation of individual subunits. To understand the connection between asymmetry and activation, we used single-particle cryo-EM to solve sixteen structures of nanodisc-reconstituted CorA. We utili ...[more]