Dataset Information
Structure of the IFN-lambda3/IFN-lambdaR1/IL-10Rbeta receptor complex with an engineered IL-10Rbeta
Ontology highlight
ABSTRACT:
SUBMITTER: Minglei Zhao
PROVIDER: EMPIAR-12502 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural studies of the IFNλ4 receptor complex using cryoEM enabled by protein engineering.
Nature communications 20250118 1
IFNλ4 has posed a conundrum in human immunology since its discovery in 2013, with its expression linked to complications with viral clearance. While genetic and cellular studies revealed the detrimental effects of IFNλ4 expression, extensive structural and functional characterization has been limited by the inability to express and purify the protein, complicating explanations of its paradoxical behavior. In this work, we report a method for robust production of IFNλ4. We then use yeast surface ...[more]