Dataset Information
GLIC in MSP1E3D1 nanodisc at pH 5.5
Ontology highlight
ABSTRACT:
SUBMITTER: Sandip Basak
PROVIDER: EMPIAR-12511 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment.
Nature communications 20240405 1
GLIC, a proton-activated prokaryotic ligand-gated ion channel, served as a model system for understanding the eukaryotic counterparts due to their structural and functional similarities. Despite extensive studies conducted on GLIC, the molecular mechanism of channel gating in the lipid environment requires further investigation. Here, we present the cryo-EM structures of nanodisc-reconstituted GLIC at neutral and acidic pH in the resolution range of 2.6 - 3.4 Å. In our apo state at pH 7.5, the e ...[more]