Dataset Information
Cryo-electron tomography of neuronal synapses, Munc13-SNAP25 project
Ontology highlight
ABSTRACT:
SUBMITTER: Vladan Lucic
PROVIDER: EMPIAR-12512 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.
Science advances 20230621 25
Synaptic vesicle tethering, priming, and neurotransmitter release require a coordinated action of multiple protein complexes. While physiological experiments, interaction data, and structural studies of purified systems were essential for our understanding of the function of the individual complexes involved, they cannot resolve how the actions of individual complexes integrate. We used cryo-electron tomography to simultaneously image multiple presynaptic protein complexes and lipids at molecula ...[more]
