Cryo-electron micrographs of Cholinephosphotransferase in complex with diacylglycerol
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ABSTRACT:
SUBMITTER: Jacquelyn Renee Roberts
PROVIDER: EMPIAR-12542 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase.
Roberts Jacquelyn R JR Horibata Yasuhiro Y Kwarcinski Frank E FE Lam Vinson V Raczkowski Ashleigh M AM Hubbard Akane A White Betsy B Sugimoto Hiroyuki H Tall Gregory G GG Ohi Melanie D MD Maeda Shoji S
Nature communications 20250102 1
Phospholipids are the most abundant component in lipid membranes and are essential for the structural and functional integrity of the cell. In eukaryotic cells, phospholipids are primarily synthesized de novo through the Kennedy pathway that involves multiple enzymatic processes. The terminal reaction is mediated by a group of cytidine-5'-diphosphate (CDP)-choline /CDP-ethanolamine-phosphotransferases (CPT/EPT) that use 1,2-diacylglycerol (DAG) and CDP-choline or CDP-ethanolamine to produce phos ...[more]
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