Dataset Information
Human TRPM4 ion channel in MAASTY copolymer lipid nanodisc in a calcium-bound state
Ontology highlight
ABSTRACT:
SUBMITTER: Ciara Frances Pugh
PROVIDER: EMPIAR-12546 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
MAASTY: a (dis)ordered copolymer for structural determination of human membrane proteins in native nanodiscs.
Nature communications 20251210 1
Amphiphilic copolymers capable of extracting membrane proteins directly from cellular membranes into "native nanodiscs" offer a simplified approach for preparing membrane proteins in lipid nanodiscs compared to approaches that rely on detergent. Copolymer amphiphilicity, length, and composition influence their performance, in addition to the protein itself and the purification conditions used. Here, we report a copolymer composed of methacrylic acid and styrene, which we term MAASTY, leveraging ...[more]