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Cryo-EM micrographs of purified human BIRC6 in presence of MAP1LC3B


ABSTRACT:

SUBMITTER: Juraj Ahel 

PROVIDER: EMPIAR-12561 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.

Ehrmann Julian F JF   Grabarczyk Daniel B DB   Heinke Maria M   Deszcz Luiza L   Kurzbauer Robert R   Hudecz Otto O   Shulkina Alexandra A   Gogova Rebeca R   Meinhart Anton A   Versteeg Gijs A GA   Clausen Tim T  

Science (New York, N.Y.) 20230209 6637


Inhibitor of apoptosis proteins (IAPs) bind to pro-apoptotic proteases, keeping them inactive and preventing cell death. The atypical ubiquitin ligase BIRC6 is the only essential IAP, additionally functioning as a suppressor of autophagy. We performed a structure-function analysis of BIRC6 in complex with caspase-9, HTRA2, SMAC, and LC3B, which are critical apoptosis and autophagy proteins. Cryo-electron microscopy structures showed that BIRC6 forms a megadalton crescent shape that arcs around a  ...[more]

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