Ontology highlight
ABSTRACT:
SUBMITTER: Juraj Ahel
PROVIDER: EMPIAR-12561 | biostudies-other |
REPOSITORIES: biostudies-other
Ehrmann Julian F JF Grabarczyk Daniel B DB Heinke Maria M Deszcz Luiza L Kurzbauer Robert R Hudecz Otto O Shulkina Alexandra A Gogova Rebeca R Meinhart Anton A Versteeg Gijs A GA Clausen Tim T
Science (New York, N.Y.) 20230209 6637
Inhibitor of apoptosis proteins (IAPs) bind to pro-apoptotic proteases, keeping them inactive and preventing cell death. The atypical ubiquitin ligase BIRC6 is the only essential IAP, additionally functioning as a suppressor of autophagy. We performed a structure-function analysis of BIRC6 in complex with caspase-9, HTRA2, SMAC, and LC3B, which are critical apoptosis and autophagy proteins. Cryo-electron microscopy structures showed that BIRC6 forms a megadalton crescent shape that arcs around a ...[more]