Dataset Information
Cryo-EM structure of human MPC in complex with UK5099 in LMNG
Ontology highlight
ABSTRACT:
SUBMITTER: Liang Feng
PROVIDER: EMPIAR-12619 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of mitochondrial pyruvate carrier and its inhibition mechanism.
Nature 20250305 8061
The mitochondrial pyruvate carrier (MPC) governs the entry of pyruvate-a central metabolite that bridges cytosolic glycolysis with mitochondrial oxidative phosphorylation-into the mitochondrial matrix<sup>1-5</sup>. It thus serves as a pivotal metabolic gatekeeper and has fundamental roles in cellular metabolism. Moreover, MPC is a key target for drugs aimed at managing diabetes, non-alcoholic steatohepatitis and neurodegenerative diseases<sup>4-6</sup>. However, despite MPC's critical roles in ...[more]