Dataset Information
Raw .tiff images of Panx1 lacking c-terminal activating domain stack 2
Ontology highlight
ABSTRACT:
SUBMITTER: Toshi Kawate
PROVIDER: EMPIAR-12634 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The C-terminal activating domain promotes pannexin 1 channel opening.
Proceedings of the National Academy of Sciences of the United States of America 20241213 51
Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of adenosine triphosphate (ATP) from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore. However, this simple pore-plugging mechanism alone cannot account for the observation that a Panx1 construct ending before the caspase cleavage site remains closed. Here, we show that a helical region located immediately befo ...[more]