Dataset Information
CryoEM structural characterization of α-Synuclein Oligomer
Ontology highlight
ABSTRACT:
SUBMITTER: Jorge Cuéllar
PROVIDER: EMPIAR-12651 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
A Targetable N-Terminal Motif Orchestrates α-Synuclein Oligomer-to-Fibril Conversion.
Journal of the American Chemical Society 20240429 18
Oligomeric species populated during α-synuclein aggregation are considered key drivers of neurodegeneration in Parkinson's disease. However, the development of oligomer-targeting therapeutics is constrained by our limited knowledge of their structure and the molecular determinants driving their conversion to fibrils. Phenol-soluble modulin α3 (PSMα3) is a nanomolar peptide binder of α-synuclein oligomers that inhibits aggregation by blocking oligomer-to-fibril conversion. Here, we investigate th ...[more]