Dataset Information
Motion corrected micrographs for CULLIN3-KLHL22-RBX1 complex
Ontology highlight
ABSTRACT:
SUBMITTER: Ming-Yuan Su
PROVIDER: EMPIAR-12669 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme.
Structure (London, England : 1993) 20231002 11
CULLIN-RING ligases constitute the largest group of E3 ubiquitin ligases. While some CULLIN family members recruit adapters before engaging further with different substrate receptors, homo-dimeric BTB-Kelch family proteins combine adapter and substrate receptor into a single polypeptide for the CULLIN3 family. However, the entire structural assembly and molecular details have not been elucidated to date. Here, we present a cryo-EM structure of the CULLIN3<sup>RBX1</sup> in complex with Kelch-lik ...[more]