Dataset Information
Escherichia coli SduA complex
Ontology highlight
ABSTRACT:
SUBMITTER: Martin Jinek
PROVIDER: EMPIAR-12726 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
DNA end sensing and cleavage by the Shedu anti-phage defense system.
Cell 20241231 3
The detection of molecular patterns associated with invading pathogens is a hallmark of innate immune systems. Prokaryotes deploy sophisticated host defense mechanisms in innate anti-phage immunity. Shedu is a single-component defense system comprising a putative nuclease SduA. Here, we report cryoelectron microscopy (cryo-EM) structures of apo- and double-stranded DNA (dsDNA)-bound tetrameric SduA assemblies, revealing that the N-terminal domains of SduA form a clamp that recognizes free DNA en ...[more]
