Dataset Information
Cryo-electron tomography on synaptic vesicles isolated from mouse brain (part 1)
Ontology highlight
ABSTRACT:
SUBMITTER: Mikhail Kudryashev
PROVIDER: EMPIAR-12794 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular architecture of synaptic vesicles.
Proceedings of the National Academy of Sciences of the United States of America 20241127 49
Synaptic vesicles (SVs) store and transport neurotransmitters to the presynaptic active zone for release by exocytosis. After release, SV proteins and excess membrane are recycled via endocytosis, and new SVs can be formed in a clathrin-dependent manner. This process maintains complex molecular composition of SVs through multiple recycling rounds. Previous studies explored the molecular composition of SVs through proteomic analysis and fluorescent microscopy, proposing a model for an average SV ...[more]
