Dataset Information
70S initiation complex (tRNA-fMet M1, initiation factor 2 + CUG start codon)
Ontology highlight
ABSTRACT:
SUBMITTER: Christine M Dunham
PROVIDER: EMPIAR-12816 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural analysis of noncanonical translation initiation complexes.
The Journal of biological chemistry 20240901 10
Translation initiation is a highly regulated, multi-step process that is critical for efficient and accurate protein synthesis. In bacteria, initiation begins when mRNA, initiation factors, and a dedicated initiator fMet-tRNA<sup>fMet</sup> bind the small (30S) ribosomal subunit. Specific binding of fMet-tRNA<sup>fMet</sup> in the peptidyl (P) site is mediated by the inspection of the fMet moiety by initiation factor IF2 and of three conserved G-C base pairs in the tRNA anticodon stem by the 30S ...[more]