Dataset Information
Cryo ET of Native Hippocampal Glutamatergic Synapses Using Dimeric AuNP Labeling
Ontology highlight
ABSTRACT:
SUBMITTER: Hoyoung kim
PROVIDER: EMPIAR-12892 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Dimeric gold nanoparticles enable multiplexed labeling in cryoelectron tomography.
Proceedings of the National Academy of Sciences of the United States of America 20251124 48
Cryoelectron tomography (cryo-ET) enables three-dimensional visualization of molecular structures within tissue and intact cells, providing a powerful tool for studying the spatial organization of biological components at nanometer resolution. Realizing this potential, particularly for submegadalton complexes, is facilitated by fiducial-based labeling. Gold nanoparticles (AuNPs) have emerged as powerful electron-dense labels for cryo-ET, but multiplexing using only conventional monomeric AuNPs i ...[more]