Dataset Information
Cryo electron micrographs of RyR2-R420W with calcium and calmodulin
Ontology highlight
ABSTRACT:
SUBMITTER: Marco Cesar Miotto
PROVIDER: EMPIAR-12901 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for ryanodine receptor type 2 leak in heart failure and arrhythmogenic disorders.
Nature communications 20240915 1
Heart failure, the leading cause of mortality and morbidity in the developed world, is characterized by cardiac ryanodine receptor 2 channels that are hyperphosphorylated, oxidized, and depleted of the stabilizing subunit calstabin-2. This results in a diastolic sarcoplasmic reticulum Ca<sup>2+</sup> leak that impairs cardiac contractility and triggers arrhythmias. Genetic mutations in ryanodine receptor 2 can also cause Ca<sup>2+</sup> leak, leading to arrhythmias and sudden cardiac death. Here ...[more]