Dataset Information
Single particle structure of mCELSR1 extracellular region containing CADH9-GAIN domains
Ontology highlight
ABSTRACT:
SUBMITTER: Sumit J. Bandekar
PROVIDER: EMPIAR-12938 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural basis for regulation of CELSR1 by a compact module in its extracellular region.
Nature communications 20250428 1
The Cadherin EGF Laminin G seven-pass G-type receptor subfamily (CELSR/ADGRC) is one of the most conserved among adhesion G protein-coupled receptors and is essential for animal development. The extracellular regions (ECRs) of CELSRs are large with 23 adhesion domains. However, molecular insight into CELSR function is sparsely available. Here, we report the 3.8 Å cryo-EM reconstruction of the mouse CELSR1 ECR and reveal that 14 domains form a compact module mediated by conserved interactions maj ...[more]