Dataset Information
Tyrocidine synthetase modules 1 and 2 crosslinked in the condensation state, complex A
Ontology highlight
ABSTRACT:
SUBMITTER: Graham W Heberlig
PROVIDER: EMPIAR-13006 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis.
Nature 20241211 8049
Non-ribosomal peptide synthetases are assembly line biosynthetic pathways that are used to produce critical therapeutic drugs and are typically arranged as large multi-domain proteins called megasynthetases<sup>1</sup>. They synthesize polypeptides using peptidyl carrier proteins that shuttle each amino acid through modular loading, modification and elongation<sup>2</sup> steps, and remain challenging to structurally characterize, owing in part to the inherent dynamics of their multi-domain and ...[more]