Dataset Information
Single particle cryoEM structure of Latrophilin-3 (ADGRL3) HormR and GAIN domains in the context of the holoreceptor
Ontology highlight
ABSTRACT:
SUBMITTER: Sumit J. Bandekar
PROVIDER: EMPIAR-13032 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Conformational coupling between extracellular and transmembrane domains modulates holo-adhesion GPCR function.
Nature communications 20241204 1
Adhesion G Protein-Coupled Receptors (aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain extracellular regions (ECRs) containing a conserved GAIN domain that precedes their seven-pass transmembrane domain (7TM). Ligand binding and mechanical force applied on the ECR regulate receptor function. However, how the ECR communicates with the 7TM remains elusive, because the relative orientation and dynamics of the ECR and 7TM within a h ...[more]