Dataset Information
E.coli BAM-hinge supressor (BamA-LVPR-T434A)
Ontology highlight
ABSTRACT:
SUBMITTER: Neil Ranson
PROVIDER: EMPIAR-13041 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Molecular insights into how the motions of the β-barrel and POTRA domains of BamA are coupled for efficient function.
Nature communications 20251003 1
The β-barrel assembly machinery (BAM) inserts β-barrel proteins into the outer membrane of Gram-negative bacteria, forming an essential permeability barrier. The core BAM component, BamA, is a β-barrel protein with an N-terminal periplasmic extension comprising five polypeptide transport-associated (POTRA) domains. Whilst BamA's structure is well characterised, it remains unclear how β-barrel and POTRA domain motions are coordinated. Using BamA variants with mutations in the hinge region between ...[more]
