Dataset Information
Single particle cryoEM data of Mycobacterium smegmatis EtfD
Ontology highlight
ABSTRACT:
SUBMITTER: John L Rubinstein
PROVIDER: EMPIAR-13058 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Mycobacterial EtfD contains an unusual linear [3Fe-4S] cluster and enables β-oxidation to drive proton pumping by the electron transport chain.
bioRxiv : the preprint server for biology 20250515
In mycobacteria, the protein EtfD is thought to link β-oxidation of fatty acids with the electron transport chain, two processes that have attracted attention as targets for therapeutics to treat tuberculosis (TB) and other mycobacterial infections. It has been proposed that targeting β- oxidation could shorten treatment duration by killing non-replicating <i>Mycobacterium tuberculosis</i> within granulomas in the lungs. Here we show that <i>Mycobacterium smegmatis</i> , a fast growing and nonpa ...[more]