Dataset Information
Common beta cytokine complex micrographs
Ontology highlight
ABSTRACT:
SUBMITTER: Nathanael A Caveney
PROVIDER: EMPIAR-13068 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling.
Molecular cell 20240412 10
Cytokines regulate immune responses by binding to cell surface receptors, including the common subunit beta (βc), which mediates signaling for GM-CSF, IL-3, and IL-5. Despite known roles in inflammation, the structural basis of IL-5 receptor activation remains unclear. We present the cryo-EM structure of the human IL-5 ternary receptor complex, revealing architectural principles for IL-5, GM-CSF, and IL-3. In mammalian cell culture, single-molecule imaging confirms hexameric IL-5 complex formati ...[more]