Dataset Information
Cryo-electron microscopy of crosslinked LetAB from Escherichia coli
Ontology highlight
ABSTRACT:
SUBMITTER: Gira Bhabha
PROVIDER: EMPIAR-13075 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
LetA defines a structurally distinct transporter family involved in lipid trafficking.
bioRxiv : the preprint server for biology 20250322
Membrane transport proteins translocate diverse cargos, ranging from small sugars to entire proteins, across cellular membranes. A few structurally distinct protein families have been described that account for most of the known membrane transport processes. However, many membrane proteins with predicted transporter functions remain uncharacterized. We determined the structure of <i>E. coli</i> LetAB, a phospholipid transporter involved in outer membrane integrity, and found that LetA adopts a d ...[more]