Dataset Information
GLIC F116A mutant in MSP1E3D1 nanodisc at pH 2.5
Ontology highlight
ABSTRACT:
SUBMITTER: Sandip Basak
PROVIDER: EMPIAR-13085 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM.
Proceedings of the National Academy of Sciences of the United States of America 20251023 43
Pentameric ligand-gated ion channels (pLGICs) are vital neurotransmitter receptors that are key therapeutic targets for neurological disorders. Although the high-resolution structures of these channels have been elucidated, capturing their dynamic conformational transitions remains challenging due to the transient nature of intermediate states. In this study, we investigated a prokaryotic proton-gated pLGIC, GLIC. In our cryo-EM data at pH 4.0, we identified and segregated asymmetric particles, ...[more]