Dataset Information
Single particle cryo-EM dataset of as-prepared Bos taurus mitochondrial complex I in MSP2N2 nanodiscs treated with NADH
Ontology highlight
ABSTRACT:
SUBMITTER: Judy Hirst
PROVIDER: EMPIAR-13115 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Post-catalysis structures of mitochondrial complex I with ubiquinol-10 bound in the active site.
Nature communications 20260305 1
Respiratory complex I is a multi-subunit energy-transducing membrane enzyme essential for mitochondrial and cellular energy metabolism. It couples NADH oxidation and ubiquinone-10 (Q<sub>10</sub>) reduction to the concomitant pumping of four protons to generate the proton-motive force that powers oxidative phosphorylation. Despite recent advances in structural knowledge of complex I, many mechanistic aspects including the reactive binding poses of Q<sub>10</sub>, how Q<sub>10</sub> reduction ini ...[more]
