Dataset Information
Cryo-EM of connexin-46/50 in DMPC nanodiscs at neutral pH (Collection #3)
Ontology highlight
ABSTRACT:
SUBMITTER: Joshua Michael Jarodsky
PROVIDER: EMPIAR-13131 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Reversible lipid-mediated pH-gating of connexin-46/50 by cryo-EM.
Nature communications 20260112 1
Gap junctions, formed by connexin proteins, establish direct electrical and metabolic coupling between cells, enabling coordinated tissue responses. These channels universally respond to intracellular pH changes, closing under acidic conditions to limit the spread of cytotoxic signals during cellular stress, such as ischemia. Using cryo-electron microscopy (cryo-EM), we uncover insights into the structural mechanism of pH-gating in native lens connexin-46/50 (Cx46/50) gap junctions. Mild acidifi ...[more]