Dataset Information
FIB-SEM imaging of control HeLa cells, cells expressing WT STARD3, and cells expressing the STARD3 FA/YA mutant
Ontology highlight
ABSTRACT:
SUBMITTER: Fabien ALPY
PROVIDER: EMPIAR-13156 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch.
The EMBO journal 20260225 7
Membrane contact sites (MCS) are dynamic regions where the membranes of two organelles come into close apposition. MCSs play many roles in cellular homeostasis by facilitating inter-organelle lipid exchange and organelle positioning. The late endosome/lysosome (LE/Lys) cholesterol transfer protein STARD3 forms reversible contacts between LE/Lys and the endoplasmic reticulum (ER). This tether protein contains a Phospho-FFAT motif (two phenylalanines in an acidic tract) whose interaction with ER-r ...[more]