Dataset Information
Cryo-EM structure of the human Erlin2 complex
Ontology highlight
ABSTRACT:
SUBMITTER: Qian HW
PROVIDER: EMPIAR-13272 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural insights into the organization of the human Erlin complex.
Journal of molecular cell biology 20260102
The endoplasmic reticulum (ER) lipid raft proteins (Erlins) belong to the stomatin-prohibitin-flotillin-HflC/K (SPFH) family and form highly oligomeric platforms that mediate the degradation of activated inositol 1,4,5-trisphosphate receptors by facilitating their interaction with the E3 ligase RNF170. However, the molecular mechanisms underlying this process remain unclear. Here, we successfully reconstituted the Erlin1-Erlin2 complex and its complex with RNF170 by overexpressing these componen ...[more]