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Cryo electron tomography of mouse hippocampal CA1-py dataset


ABSTRACT:

SUBMITTER: Calina Glynn 

PROVIDER: EMPIAR-13303 | biostudies-other |

REPOSITORIES: biostudies-other

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Publications

A generalizable and targeted molecular biopsy approach for in situ cryogenic electron tomography of vitreous brain tissue.

Glynn Calina C   Smith Jake L R JLR   Case Matthew M   Csöndör Rebecca R   Katsini Ana A   Sanita Maria E ME   Glen Thomas S TS   Pennington Avery A   Grange Michael M  

Cell reports methods 20250616 7


Cellular cryogenic electron tomography (cryo-ET) enables the capture of detailed structural information within a biologically relevant environment. However, information in more complex samples, such as multicellular specimens and tissues, is lacking. Importantly, these observations need to be set in the context of populations. Currently, imaging on the molecular scale is limited to a few observations in situ that struggle to be generalized. This is due to limitations in throughput and versatilit  ...[more]

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