Dataset Information
E. coli 70S ribosome with unmodified lys-tRNAPro(GGG) bound to slippery P-site CCC-C codon
Ontology highlight
ABSTRACT:
SUBMITTER: Jacob Michael Mattingly
PROVIDER: EMPIAR-13308 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
An RNA modification prevents extended codon-anticodon interactions from facilitating +1 frameshifting.
Nature communications 20250811 1
RNA post-transcriptional modifications act by stabilizing the functional conformations of RNA. While their role in messenger RNA (mRNA) decoding is well established, it is less clear how transfer RNA (tRNA) modifications outside the anticodon contribute to tRNA stability and accurate protein synthesis. Absence of such modifications causes translation errors, including mRNA frameshifting. By integrating single-molecule fluorescence resonance energy transfer and cryogenic electron microscopy, we d ...[more]