Dataset Information
Cryo-EM structures of alpha5beta1 integrin in complex with NeoNectin candidate 2, open and closed conformation
Ontology highlight
ABSTRACT:
SUBMITTER: Rachel Werther
PROVIDER: EMPIAR-13332 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
De Novo Design of Integrin α5β1 Modulating Proteins to Enhance Biomaterial Properties.
Advanced materials (Deerfield Beach, Fla.) 20250609 34
Integrin α5β1 is crucial for cell attachment and migration in development and tissue regeneration, and α5β1 binding proteins can have considerable utility in regenerative medicine and next-generation therapeutics. We use computational protein design to create de novo α5β1-specific modulating miniprotein binders, called NeoNectins, that bind to and stabilize the open state of α5β1. When immobilized onto titanium surfaces and throughout 3D hydrogels, the NeoNectins outperform native fibronectin (F ...[more]