Dataset Information
Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed
Ontology highlight
ABSTRACT:
SUBMITTER: Niels Fischer
PROVIDER: EMPIAR-13386 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Membrane insertion of mitochondrial-encoded proteins regulates ribosome decoding speed.
Nature structural & molecular biology 20260507 5
The human mitochondrial genome encodes 13 subunits of the oxidative phosphorylation system essential for energy metabolism to drive cellular activities. Translation of 11 mRNAs by membrane-bound ribosomes is coupled to insertion of the nascent polypeptides into the inner membrane aided by the OXA1L insertase. To this end, the mechanism of membrane insertion of nascent polypeptides and the functional link to the translation process are not sufficiently understood. Here, we applied ribosome profil ...[more]
