Dataset Information
C. thermocellum UvrA in complex with unmodified DNA and AMPPNP
Ontology highlight
ABSTRACT:
SUBMITTER: Mariusz Czarnocki-Cieciura
PROVIDER: EMPIAR-13394 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA.
Nature communications 20251211 1
Nucleotide excision repair is a DNA repair pathway which detects and fixes various DNA lesions that distort the structure of DNA. In bacteria, the pathway starts with the UvrA protein which has two adenosine triphosphatase modules and forms dimers. The DNA is handed over from UvrA to UvrB, which is a weak helicase that verifies the presence of damage. Despite intense studies, the role of the ATPase activity of UvrA in damage recognition is unclear. Here, we present a series of cryo-electron micr ...[more]