Dataset Information
Macaque green and red cone pigments
Ontology highlight
ABSTRACT:
SUBMITTER: Kota Katayama
PROVIDER: EMPIAR-13418 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structure of the intact ATM/Tel1 kinase.
Nature communications 20160527
The ataxia-telangiectasia mutated (ATM) protein is an apical kinase that orchestrates the multifaceted DNA-damage response. Normally, ATM kinase is in an inactive, homodimer form and is transformed into monomers upon activation. Besides a conserved kinase domain at the C terminus, ATM contains three other structural modules, referred to as FAT, FATC and N-terminal helical solenoid. Here we report the first cryo-EM structure of ATM kinase, which is an intact homodimeric ATM/Tel1 from Schizosaccha ...[more]