Dataset Information
Cryo-EM structure of the aspartate:alanine antiporter AspT WT
Ontology highlight
ABSTRACT:
SUBMITTER: Takeshi Kawabata
PROVIDER: EMPIAR-13423 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Elucidation of the structure and molecular mechanisms of the aspartate antiporter.
Communications biology 20250925 1
The transport of compounds across the cell membrane is essential for maintaining cellular homeostasis. Secondary exchange transporters mediate the movement of a wide range of substrates against their concentration gradients by harnessing the energy stored in electrochemical gradients. However, the molecular mechanism of substrate exchange by secondary transporters remains unclear. Here, we determined the structures of the aspartate exchanger AspT from Tetragenococcus halophilus using cryo-EM sin ...[more]
