Dataset Information
Alpha-hemolysin in the lipidic environment
Ontology highlight
ABSTRACT:
SUBMITTER: Somnath Dutta
PROVIDER: EMPIAR-13453 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Structural insights into pre-pore intermediates of alpha-hemolysin in the lipidic environment.
Nature communications 20250710 1
The infectious microbe Staphylococcus aureus releases an array of cytotoxic pore-forming toxins (PFTs) that severely damage the cell membrane during bacterial infection. However, the interaction interfaces between the host cell membrane and toxin were hardly explored. So far, there are no pore, and intermediate structures of these toxins available in the presence of bio-membrane, which could elucidate the pore-forming mechanism. Here, we investigate the structure of different conformational stat ...[more]
