Dataset Information
BG505.SOSIP.664.T332N gp140 trimer in complex with 44m bnAb
Ontology highlight
ABSTRACT:
SUBMITTER: Somnath Dutta
PROVIDER: EMPIAR-13456 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Recognition determinants of improved HIV-1 neutralization by a heavy chain matured pediatric antibody.
iScience 20230809 9
The structural and characteristic features of HIV-1 broadly neutralizing antibodies (bnAbs) from chronically infected pediatric donors are currently unknown. Herein, we characterized a heavy chain matured HIV-1 bnAb 44m, identified from a pediatric elite-neutralizer. Interestingly, in comparison to its wild-type AIIMS-P01 bnAb, 44m exhibited moderately higher level of somatic hypermutations of 15.2%. The 44m neutralized 79% of HIV-1 heterologous viruses (n = 58) tested, with a geometric mean IC< ...[more]