Dataset Information
Tau Paired Helical Filament from Alzheimer's Disease incubated with D-peptide D-TLKIVWI
Ontology highlight
ABSTRACT:
SUBMITTER: Peng Ge
PROVIDER: EMPIAR-13488 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
How short peptides disassemble tau fibrils in Alzheimer's disease.
Nature 20250709 8078
Reducing fibrous aggregates of the protein tau is a possible strategy for halting the progression of Alzheimer's disease (AD)<sup>1</sup>. Previously, we found that in vitro, the D-enantiomeric peptide (D-peptide) D-TLKIVWC disassembles ultra-stable tau fibrils extracted from the autopsied brains of individuals with AD (hereafter, these tau fibrils are referred to as AD-tau) into benign segments, with no energy source other than ambient thermal agitation<sup>2</sup>. To consider D-peptide-mediat ...[more]