Dataset Information
Methyltransferase RmtC bound to the 30S ribosomal subunit
Ontology highlight
ABSTRACT:
SUBMITTER: Christine M Dunham
PROVIDER: EMPIAR-13701 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtC.
Proceedings of the National Academy of Sciences of the United States of America 20230612 25
Acquired ribosomal RNA (rRNA) methylation has emerged as a significant mechanism of aminoglycoside resistance in pathogenic bacterial infections. Modification of a single nucleotide in the ribosome decoding center by the aminoglycoside-resistance 16S rRNA (m<sup>7</sup>G1405) methyltransferases effectively blocks the action of all 4,6-deoxystreptamine ring-containing aminoglycosides, including the latest generation of drugs. To define the molecular basis of 30S subunit recognition and G1405 modi ...[more]
