Dataset Information
Cryo-EM structure of Pseudomonas aeruginosa Recombinase A (RecA) in complex with LexAS125A mutant
Ontology highlight
ABSTRACT:
SUBMITTER: Sofia De Felice
PROVIDER: EMPIAR-13704 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Snapshots of <i>Pseudomonas aeruginosa</i> SOS response reveal structural requisites for LexA autoproteolysis.
iScience 20250102 2
Antimicrobial resistance poses a severe threat to human health and <i>Pseudomonas aeruginosa</i> stands out among the pathogens responsible for this emergency. The SOS response to DNA damage is crucial in bacterial evolution, influencing resistance development and adaptability in challenging environments, especially under antibiotic exposure. Recombinase A (RecA) and the transcriptional repressor LexA are the key players that orchestrate this process, determining either the silencing or the acti ...[more]