Dataset Information
STING mutants in detergent LMNG/CHS
Ontology highlight
ABSTRACT:
SUBMITTER: Pengbiao Xu
PROVIDER: EMPIAR-13713 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
The mutational landscape of STING-induced immunity.
Nature 20260624
Stimulator of interferon genes (STING) is an evolutionary conserved immune signalling protein with key roles in host defence, cancer, senescence and inflammation<sup>1-3</sup>. Downstream of STING, type I interferon, inflammatory cytokine signalling and non-canonical autophagy are governed by a multilayered mechanism integrating ligand-induced structural transitions, protein-protein interactions and coordinated intracellular trafficking<sup>4-13</sup>. Despite its central role in immunity and re ...[more]
