Faville2008_UPdepolarization

ABSTRACT:

This a model from the article:
A biophysically based mathematical model of unitary potential activity ininterstitial cells of Cajal.
Faville RA, Pullan AJ, Sanders KM, Smith NP. Biophys J 2008 Jul;95(1):88-104 18339738 ,
Abstract:
Unitary potential (UP) depolarizations are the basic intracellular eventsresponsible for pacemaker activity in interstitial cells of Cajal (ICCs), andare generated at intracellular sites termed "pacemaker units". In this study, wepresent a mathematical model of the transmembrane ion flows and intracellularCa(2+) dynamics from a single ICC pacemaker unit acting at near-resting membranepotential. This model quantitatively formalizes the framework of a novel ICCpacemaking mechanism that has recently been proposed. Model simulations producespontaneously rhythmic UP depolarizations with an amplitude of approximately 3mV at a frequency of 0.05 Hz. The model predicts that the main inward currents,carried by a Ca(2+)-inhibited nonselective cation conductance, are activated bydepletion of sub-plasma-membrane [Ca(2+)] caused by sarcoendoplasmic reticulumcalcium ATPase Ca(2+) sequestration. Furthermore, pacemaker activity predictedby our model persists under simulated voltage clamp and is independent of[IP(3)] oscillations. The model presented here provides a basis toquantitatively analyze UP depolarizations and the biophysical mechanismsunderlying their production.

This model was taken from the CellML repository and automatically converted to SBML.
The original model was: Faville RA, Pullan AJ, Sanders KM, Smith NP. (2008) - version02
The original CellML model was created by:
Lloyd, Catherine, May
[e-mail]
The University of Auckland
The Bioengineering Institute

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ORGANISM(S): Homo sapiens

SUBMITTER: Vijayalakshmi Chelliah 

PROVIDER: MODEL0912044015 | biostudies-other |

SECONDARY ACCESSION(S): 18339738

REPOSITORIES: biostudies-other